It will be necessary, without a doubt, to continue investigating the prognosis of the RA, which would imply on the one hand having knowledge of the long-term results of the different prospective studies that are being carried out.
Likewise, it would be necessary to identify new prognostic variables such as, for example, genetic markers outside the HLA system, biological parameters such as antifilagrin or other antibodies, immunohistological data (expression of cytokines or proteases in the rheumatoid synovium) Keto Viante, as well as elaborate outcome measures more reliable or that detect more early the joint damage, such as imaging techniques such as ultrasound or magnetic resonance imaging.
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